Epoetin zeta
Epoetin zeta is a protein pharmaceutical. Epoetin zeta was first approved as Retacrit on 2007-12-18. It has been approved in Europe to treat anemia, autologous blood transfusion, chronic kidney failure, and neoplasms.
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789 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | HP_0001903 | D64.9 | 11 | 103 | 128 | 68 | 50 | 352 |
| Chronic renal insufficiency | D051436 | — | N18 | 8 | 24 | 27 | 10 | 19 | 87 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 7 | 21 | 18 | 12 | 11 | 66 |
| Neoplasms | D009369 | — | C80 | 1 | 14 | 14 | 5 | 11 | 45 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 21 | 11 | 2 | 5 | 38 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 2 | — | 4 | 8 | 15 |
| Lymphoma | D008223 | — | C85.9 | 1 | 3 | 7 | 1 | 2 | 14 |
| Iron-deficiency anemia | D018798 | HP_0001891 | D50 | 1 | 2 | 3 | 4 | 5 | 14 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 2 | 4 | 1 | 2 | 8 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 6 | 1 | — | 8 |
Show 36 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | 3 | 1 | — | 4 | 22 |
| Leukemia | D007938 | — | C95 | — | 5 | 7 | — | 1 | 13 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 5 | 4 | — | 1 | 8 |
| Plasma cell neoplasms | D054219 | — | — | — | 2 | 5 | — | 1 | 8 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | 3 | — | 3 | 7 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 4 | 2 | — | 1 | 7 |
| Cerebral palsy | D002547 | — | G80 | 1 | 2 | 1 | — | 3 | 7 |
| Brain hypoxia-ischemia | D020925 | EFO_1000846 | P91.6 | 4 | 3 | 3 | — | — | 7 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | 4 | 2 | — | 2 | 7 |
| Blood transfusion | D001803 | — | — | — | 4 | 5 | — | 1 | 7 |
Show 70 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 5 | — | — | — | 5 |
| Ischemic stroke | D000083242 | — | — | 3 | 2 | — | — | — | 4 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 2 | 1 | — | — | 1 | 3 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 2 | — | — | 1 | 3 |
| Congenital heart defects | D006330 | HP_0001627 | Q24.9 | 1 | 2 | — | — | 1 | 3 |
| Critical illness | D016638 | — | — | — | 2 | — | — | 1 | 3 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | — | 3 | — | — | — | 3 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 1 | — | — | — | 2 |
| Retinopathy of prematurity | D012178 | EFO_1001158 | H35.1 | 1 | 1 | — | — | 1 | 2 |
| Reperfusion injury | D015427 | — | — | — | 1 | — | — | 1 | 2 |
Show 35 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 2 | 3 |
| Reticulocyte count | D017701 | — | — | 1 | — | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Autoimmune hepatitis | D019693 | — | K75.4 | 1 | — | — | — | — | 1 |
| Hypogonadism | D007006 | HP_0000044 | E23.0 | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
| Alveolar bone loss | D016301 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | — | 2 | 2 |
| Surgical blood loss | D016063 | — | — | — | — | — | — | 2 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 2 | 2 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 2 | 2 |
| Continuous ambulatory peritoneal dialysis | D010531 | — | — | — | — | — | — | 1 | 1 |
| Developmental disabilities | D002658 | EFO_0003852 | F89 | — | — | — | — | 1 | 1 |
| Iron metabolism disorders | D019189 | — | E83.1 | — | — | — | — | 1 | 1 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | — | — | — | 1 | 1 |
| Vitamin b 12 deficiency | D014806 | EFO_0000734 | E53.8 | — | — | — | — | 1 | 1 |
| Arthroplasty | D001178 | — | — | — | — | — | — | 1 | 1 |
Show 23 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Epoetin zeta |
| INN | epoetin alfa |
| Description | Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS. In these situations they decrease the need for blood transfusions. The different agents are more or less equivalent. They are given by injection.
|
| Classification | Protein |
| Drug class | erythropoietins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108593 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 64FS3BFH5W (ChemIDplus, GSRS) |
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Retacrit – Pfizer
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Safety
Black-box Warning
Black-box warning for: Epogen, Mircera, Procrit, Retacrit
Adverse Events
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39,915 adverse events reported
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