Epoetin zeta
Retacrit, Silapo (epoetin zeta) is a protein pharmaceutical. Epoetin zeta was first approved as Retacrit on 2007-12-18. It has been approved in Europe to treat anemia, autologous blood transfusion, chronic kidney failure, and neoplasms.
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811 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | 16 | 119 | 150 | 78 | 74 | 425 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 9 | 45 | 49 | 22 | 36 | 158 |
| Chronic renal insufficiency | D051436 | — | N18 | 10 | 40 | 52 | 20 | 31 | 152 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 10 | 26 | 23 | 14 | 14 | 82 |
| Renal insufficiency | D051437 | — | N19 | 9 | 22 | 24 | 14 | 9 | 74 |
| Neoplasms | D009369 | — | C80 | 1 | 17 | 16 | 5 | 12 | 51 |
| Syndrome | D013577 | — | — | 3 | 26 | 11 | 3 | 8 | 47 |
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 24 | 12 | 3 | 7 | 45 |
| Preleukemia | D011289 | — | — | 2 | 23 | 12 | 3 | 6 | 43 |
| Iron deficiencies | D000090463 | — | E61.1 | 1 | 3 | 4 | 6 | 10 | 22 |
Show 75 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | 3 | 1 | — | 5 | 23 |
| Leukemia | D007938 | — | C95 | — | 8 | 7 | — | 1 | 16 |
| Multiple myeloma | D009101 | — | C90.0 | — | 3 | 8 | — | 4 | 15 |
| Wounds and injuries | D014947 | — | T14.8 | 1 | 6 | 4 | — | 5 | 14 |
| Blood transfusion | D001803 | — | — | — | 4 | 5 | — | 6 | 12 |
| Plasma cell neoplasms | D054219 | — | — | — | 3 | 6 | — | 2 | 11 |
| Brain injuries | D001930 | — | S06.9 | — | 7 | 5 | — | 1 | 11 |
| Brain diseases | D001927 | — | G93.40 | 5 | 4 | 5 | — | — | 11 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 5 | 4 | — | 1 | 8 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 3 | 6 | 1 | — | — | 8 |
Show 103 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | 3 | 5 | — | — | — | 7 |
| Cardiac surgical procedures | D006348 | — | — | 1 | 2 | — | — | 5 | 7 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | 5 | — | — | — | 6 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | 1 | 5 | — | — | — | 6 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | 3 | — | — | 1 | 4 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | — | 1 | 4 |
| Critical illness | D016638 | — | — | — | 3 | — | — | 1 | 4 |
| Sclerosis | D012598 | — | — | 2 | 2 | — | — | — | 3 |
| Coronary artery disease | D003324 | — | I25.1 | — | 3 | — | — | — | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 2 | 1 | — | — | 1 | 3 |
Show 68 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 2 | 3 |
| Aids-related complex | D000386 | EFO_0007137 | B20 | 1 | — | — | — | 2 | 3 |
| Cerebral infarction | D002544 | — | I63 | 2 | — | — | — | — | 2 |
| Reticulocyte count | D017701 | — | — | 1 | — | — | — | — | 1 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Autoimmune hepatitis | D019693 | — | K75.4 | 1 | — | — | — | — | 1 |
| Hypogonadism | D007006 | — | E23.0 | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
| Cerebral hemorrhage | D002543 | — | — | 1 | — | — | — | — | 1 |
| Liver transplantation | D016031 | EFO_0010682 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cytopenia | D000095542 | — | — | — | — | — | — | 9 | 9 |
| Pancytopenia | D010198 | — | D61.81 | — | — | — | — | 8 | 8 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | — | 2 | 2 |
| Iron metabolism disorders | D019189 | — | E83.1 | — | — | — | — | 2 | 2 |
| Hemolytic anemia | D000743 | — | D55-D59 | — | — | — | — | 2 | 2 |
| Surgical blood loss | D016063 | — | — | — | — | — | — | 2 | 2 |
| Respiratory insufficiency | D012131 | — | J96.9 | — | — | — | — | 2 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 2 | 2 |
| Continuous ambulatory peritoneal dialysis | D010531 | — | — | — | — | — | — | 1 | 1 |
| Developmental disabilities | D002658 | EFO_0003852 | F89 | — | — | — | — | 1 | 1 |
Show 40 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Epoetin zeta |
| INN | epoetin alfa |
| Description | Erythropoiesis-stimulating agents (ESA) are medications which stimulate the bone marrow to make red blood cells. They are used to treat anemia due to end stage kidney disease, chemotherapy, major surgery, or certain treatments in HIV/AIDS. In these situations they decrease the need for blood transfusions. The different agents are more or less equivalent. They are given by injection.
|
| Classification | Protein |
| Drug class | erythropoietins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108593 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 64FS3BFH5W (ChemIDplus, GSRS) |
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Retacrit – Pfizer
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Safety
Black-box Warning
Black-box warning for: Epogen, Mircera, Procrit, Retacrit
Adverse Events
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49,845 adverse events reported
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